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We use contemporary molecular, cellular, and biochemical techniques as well as modern genome-wide methodologies to study role of Aryl hydrocarbon Receptor (AhR), its ligands, cofactors, and target genes in liver and metabolic diseases. Our goal is to develop a translational approach to Aryl hydrocarbon Receptor biology by identifying and characterizing therapeutically useful Aryl hydrocarbon Receptor agonists to protect against plethora of hepatic diseases.